Chemical Properties
white to light yellow crystal powder
Uses
Methyl 3-amino-2-thiophenecarboxylate was used in:
- the synthesis of 4-nitro and 4-aminothienyl ureas
- total synthesis of quinazolinocarboline alkaloids
- preparation of thienopyrimidinone analogs
Uses
Methyl 3-amino-2-thiophenecarboxylate is the starting material for synthesising Belvarafenib. Belvarafenib is a small-molecule RAF dimer (type II) inhibitor with potential antitumour activity.
General Description
Methyl 3-amino-2-thiophenecarboxylate reacts with hydrazonoyl chlorides in the presence of triethylamine to yield corresponding
N-arylamidrazones.
Safety
Methyl 3-amino-2-thiophenecarboxylate is irritating to the eyes and skin. Contact may cause skin irritation and severe eye irritation. Inhalation may cause respiratory irritation.
