Description
2-
O-
methyl-
PAF C-
18 is a synthetic PAF analog which contains a methyl group, attached by an ether linkage, at the
sn-
2 position. It has been shown to mediate a number of biological responses including decreasing plasma membrane fluidity and inhibiting tumor cell invasiveness in embryonic chick heart. In rat astrocytes, 2-
O-
methyl PAF C-
18 causes the release of large quantities of nitric oxide by a pathway involving activation of nitric oxide synthase.
References
[1] WIM J. VAN BLITTERSWIJK Guy A S Henk Hilkmann. Accumulation of an alkyl lysophospholipid in tumor cell membranes affects membrane fluidity and tumor cell invasion[J]. Lipids, 1987, 22 11: 820-823. DOI:
10.1007/bf02535537[2] VENERA CARDILE. Effects of ether lipid 1-O-octadecyl-2-methoxy-rac-glycero-3-phosphocholine and its analogs PAF and CPAF on the release of nitric oxide in primary cultures of rat astrocytes[J]. Brain Research, 1996, 715 1: Pages 98-103. DOI:
10.1016/0006-8993(95)01564-7
