2-O-methyl PAF C-18 (hydrate)

2-O-methyl-PAF C-18 is a synthetic PAF analog which contains a methyl group, attached by an ether linkage, at the sn-2 position. It has been shown to mediate a number of biological responses including decreasing plasma membrane fluidity and inhibiting tumor cell invasiveness in embryonic chick heart. In rat astrocytes, 2-O-methyl PAF C-18 causes the release of large quantities of nitric oxide by a pathway involving activation of nitric oxide synthase.

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[2] VENERA CARDILE. Effects of ether lipid 1-O-octadecyl-2-methoxy-rac-glycero-3-phosphocholine and its analogs PAF and CPAF on the release of nitric oxide in primary cultures of rat astrocytes[J]. Brain Research, 1996, 715 1: Pages 98-103. DOI: 10.1016/0006-8993(95)01564-7