2-[(Cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)benzamide

Uses

ML 382 acts as a potent and selective allosteric modulator of MrgX1, used in the stufy to improve the potency and efficacy of anti-chronic pain medicaments.

Biological Activity

ML382 is a positive allosteric modulator of Mas-related G-protein-coupled receptor X1 (MrgprX1, MrgX1, SNSR4), a G-protein coupled receptor (GPCR) selectively expressed in dorsal root ganglion (DRG) neurons. MrgX1 is believed to be a functional ortholog of mouse MrgC11, which has been shown to be involved in itch and pain. ML382 is selective for MrgX1 over MrgX2, MrgC11 and a panel of 68 other GPCRs, ion channels and transporters, with an EC50 value of 190 nm with an Emax value of 148% in the presence of the known ligand BAM8-22.

in vivo

storage

Store at RT