Description
N
6-Cyclohexyladenosine is an adenosine receptor agonist. It selectively binds to adenosine A
1 receptors in rat cortical membranes (IC
50 = 2.3 nM) over A
2 receptors in rat striatal membranes (IC
50 = 870 nM). N
6-Cyclohexyladenosine decreases heart rate and increases coronary flow in a perfused working rat heart model
ex vivo (EC
25s = 5 and 860 nM, respectively).
In vivo, it decreases heart rate and blood pressure in normotensive rats (EC
25s = 2.4 and 4.2 μg/kg, respectively). N
6-Cyclohexyladenosine (100 μM) induces sleep in rats when administered
via basal forebrain infusion. N
6-Cyclohexyladenosine also decreases locomotor activity in mice (ED
50 = 60 μg/kg, i.p.).
Uses
N6-Cyclohexyladenosine is a derivative of Adenosine (A280400), and is used testing adenosine A1 and A2A receptor activation for pharmaceuticals such as antidepressants. N6-Cyclohexyladenosine also is used as a JAK2 inhibitor, blocking STAT3 signalling in human cancer cells.
