Description
N
6-Methyladenosine is an adenosine analog. It inhibits epinephrine-induced contraction of isolated guinea pig ileum and thoracic aorta when used at a concentration of 10 μM. N
6-Methyladenosine (1 mg/kg, i.v.) decreases arterial blood pressure and renal blood flow and increases peripheral resistance in anesthetized dogs. It also inhibits tumor growth in the C3H/ST and C3HB/ST mouse models of spontaneous mammary adenocarcinomas. N
6-Methyladenosine is also the most prevelant mRNA modification in eukaryotes and has roles in cell viability and development.
Uses
N6-Methyladenosine is the most common internal modification of eukaryotic mRNA. The result of this modification is specifically recognized mRNA in the cytoplasm which regulates mRNA stability.N6-Methyladenosine is made when a protein complex containin the writer enzyme METTL3 adds a methyl group to adenosine. Two different eraser enzymes ALKBH5 and FTO can remove a methyl group to turn m6A bach into adenosine.
Definition
ChEBI: A methyladenosine compound with one methyl group attached to N6 of the adenine nucleobase.
References
[1] S.W. LESLIE T. S M J L Borowitz. Adenosine Analogs: Structure-Activity Relationships in Vascular and Intestinal Smooth Muscle[J]. Journal of pharmaceutical sciences, 1973, 62 9: Pages 1449-1452. DOI:
10.1002/jps.2600620911[2] T BHANALAPH. Effect of adenosine and some of its analogs on renal hemodyamics.[J]. Journal of medicine, 1973, 4 3: 178-188.
[3] LEONELL C. STRONG PH.D. Henry M B S. Comparison of the effect of three nucleosides and a liver emulsion upon the inhibition of cancer in mice[J]. Journal of Surgical Oncology, 1972, 4 3: 248-254. DOI:
10.1002/jso.2930040308[4] XIAO WANG. N6-methyladenosine-dependent regulation of messenger RNA stability[J]. Nature, 2013, 505 7481: 117-120. DOI:
10.1038/nature12730
