3,4-Dimethylbenzophenone

Description

Synthesis

65614-94-0

2571-39-3

The general procedure for the synthesis of 3,4-dimethylbenzophenone from the compound (CAS: 65614-94-0) was carried out as follows: a magnetic stirrer was added to a Schlenk tube which had been pre-dried in an oven, and 1,2-diarylalkyn-1 (0.5 mmol), aniline (0.6 mmol), K2CO3 (0.5 mmol) and Cu(OAc)2 (0.075 mmol). Subsequently, DMSO (3 mL) was added as solvent, the reaction tube was sealed and purged by passing oxygen through a syringe. The reaction mixture was placed in an oil bath at 120 °C and the reaction was continuously stirred for 16-18 hours. Upon completion of the reaction, the reaction mixture was diluted with ethyl acetate (30 mL) and filtered through a diatomaceous earth pad. The organic phase was collected and washed sequentially with saturated NaCl solution (8 mL), saturated NH4Cl solution (8 mL) and again saturated NaCl solution (8 mL). The organic layer was dried over anhydrous Na2SO4 and concentrated under reduced pressure to remove the solvent to obtain the crude product. Finally, the crude product was purified by silica gel column chromatography (eluent: hexane/ethyl acetate gradient) to obtain the target compound 3,4-dimethylbenzophenone.

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