Vidarabine monophosphate

Description

Vidarabine monophosphate, chemical name: 9-(5-O-Phosphono-beta-D-arabinofuranosyl)adenine is an anti deoxyribonucleic acid virus drug. IVidarabine triphosphate directly inhibits DNA polymerase and also acts as a chain terminator in DNA replication. An adenosine monophosphate analog in which ribose is replaced by an arabinose moiety. It is the monophosphate ester of VIDARABINE with antiviral and possibly antineoplastic properties.

Chemical Properties

Crystalline

Uses

Antiviral.

Uses

Disrupts viral DNA synthesis. Competitive viral DNA polymerase inhibitor. Active against herpes simplex and varicella zoster viruses in vivo.

Application

Vidarabine monophosphate has broad-spectrum anti-virus effect and can inhibit a variety of DNA viruses. It is mainly used to treat chronic hepatitis B and other viral infections, such as herpes zoster, herpes simplex and genital herpes. It has quick effect and clear curative effect. It is a common drug for clinical anti-virus treatment.

Safety Profile

Moderately toxic byintraperitoneal route. When heated to decomposition itemits very toxic fumes of POx and NOx.