Description
13Z,16Z-Docosadienoic acid is a natural ω-6 polyunsaturated fatty acid (PUFA). It is an agonist of free fatty acid receptor 4 (FFAR4, also known as GPR120) and strongly inhibits the secretion of ghrelin by isolated mouse gastric cells. This 20:2 PUFA has been identified in mammals, fish, plants, and anaerobic fungi.
Uses
13(Z),16(Z)-Docosadienoic Acid, is a natural polysaturated fatty acid found in mammals, fish, plants, and anaerobic fungi. It is also an agonist of free fatty acid receptor 4 (FFAR4, also known as GPR120) and strongly inhibits the secretion of ghrelin by isolated mouse gastric cells.
Definition
ChEBI: (13Z,16Z)-docosadienoic acid is a docosadienoic acid having two cis-double bonds at position 13 and 16 respectively. It has a role as a metabolite. It is a conjugate acid of a (13Z,16Z)-docosadienoate.
IC 50
Human Endogenous Metabolite
References
[1]. x. lu, x. zhao, j. feng, et al. postprandial inhibition of gastric ghrelin secretion by long-chain fatty acid through gpr120 in isolated gastric ghrelin cells and mice. am. j. physiol. gastrointest. liver physiol. 303(3), g367-376 (2012).
[2]. kimura i. omega-3 fatty acids and ffar4[j]. obesity and diabetes: energy regulation by free fatty acid receptors, 2016: 29.
[3]. ma d w l, seo j, switzer k c, et al. n-3 pufa and membrane microdomains: a new frontier in bioactive lipid research[j]. the journal of nutritional biochemistry, 2004, 15(11): 700-706.
