Synthesis
Diethyl malonate is mixed with sodium ethoxide, and then chlorobutane is added to form the reaction. The crude product is separated and recovered ethanol, washed and dehydrated to obtain Diethyl butylmalonate.
Chemical Properties
CLEAR COLOURLESS LIQUID
Uses
Diethyl butylmalonate is used as a reagent in the synthesis of 2,5-dihydropyrrole formyl hydroxyamino derivatives as peptide deformylase inhibitors against drug-resistant bacteria.
Synthesis Reference(s)
Organic Syntheses, Coll. Vol. 1, p. 250, 1941
The Journal of Organic Chemistry, 44, p. 3492, 1979
DOI: 10.1021/jo01334a009
General Description
Diethyl malonate (DEM) undergoes alkylation by ethyliodide, which is used to study the phase transfer catalysis (PTC) technique.
Flammability and Explosibility
Not classified