3'-DEOXYGUANOSINE

Description

3''-Deoxyguanosine is a ligand that can be complexed with enzymes, such as purine nucleoside phosphorylase, and receptors, in order to study structure-activity relationships. This compound can also be used to selectively impair transcription.

Chemical Properties

solid

Uses

3’-Deoxyguanosine is a derivative of guanosine, a ligand which may be complexe with enzymes such as purine nucleoside phosphorylase and receptors. Potential anti-amoebic agent.

Definition

ChEBI: 3'-deoxyguanosine is a 3'-deoxyribonucleoside having guanine as the nucleobase. It has a role as an EC 2.7.7.48 (RNA-directed RNA polymerase) inhibitor. It is a 3'-deoxyribonucleoside and a member of guanosines.

References

[1] FERNANDA CANDURI. Structure of human PNP complexed with ligands.[J]. Acta crystallographica. Section D, Biological crystallography, 2005, 61 Pt 7: 856-862. DOI: 10.1107/s0907444905005421
[2] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.
[3] ROBERT W KING  Matthew W J  Marianne Zecher. Inhibition of the replication of a hepatitis C virus-like RNA template by interferon and 3’-deoxycytidine.[J]. Antiviral Chemistry and Chemotherapy, 2002, 13 6: 363-370. DOI: 10.1177/095632020201300604