Application
It is mainly used for pre-emergence control of annual grass weeds and most broadleaf weeds in paddy fields, and is particularly effective against barnyard grass (before and during the two-leaf stage). The dosage is 180~270g(ai)/hm2 [12~18g(ai) per mu].
Definition
ChEBI: Thenylchlor is an anilide.
Production Methods
Thenylchlor is commercially produced via a process that begins with the preparation of the substituted acetanilide intermediate by N-alkylation of 2,6-dimethylaniline with 3-methoxy-2-(chloromethyl)thiophene under phase-transfer conditions. The key acylation follows, reacting the secondary amine with chloroacetyl chloride in dichloromethane in the presence of triethylamine to form the amide linkage, minimising over-acylation through controlled addition.
Mechanism of action
Absorbs through roots, blocks protein synthesis and so inhibits cell division. Inhibition of very long chain fatty acids (VLCFA, inhibition of cell division)
Metabolic pathway
14C-Thenylchlor (NSK-850) is degraded in three kinds
of paddy soil with a half-life of 1-3 weeks after
application. Two major metabolites are identified as N-
acetyl and N-hydroxylmethylcarbonyl derivatives which
are derived from the replacement of the chlorine atom
of thenylchlor by hydrogen and hydroxyl groups,
respectively.
