Synthesis
Under argon protection, palladium acetate (0.025 mmol,0.0056 g), monophosphine ligand TFPP (0.15 mmol,0.0474 g), 0.5 mL of toluene, 6-phenyl-1-hexene (0.5 mmol,0.0801 g), formic acid (0.75 mmol,0.0345 g) and acetic anhydride (0.1 mmol,0.0102g). The bottle was sealed by screwing on the cap and the temperature of the heating plate was adjusted to 80 C. After 48 h, the heating was stopped, cooled to room temperature, and 3 mL of dichloromethane was added and transferred to a 125 mL dispensing funnel. The mother liquor was added 1M NaOH solution 30mL, washed with dichloromethane 3 times, 30mL each time. the aqueous phase was acidified with 3M hydrochloric acid 15mL, and then extracted with dichloromethane three times, 30mL each time. 0.080g of white solid 7-phenylheptanoic acid was obtained in 78% yield.
