Application
Butyltriphenylphosphine chloride is a quaternary phosphonium salt containing a monoalkyltriphenyl substituent. The phosphorus atom possesses three unpaired electrons, one lone pair of electrons, and five empty 3d orbitals, giving Ph3P+ electron-withdrawing properties. This also allows the quaternary phosphonium salt cation to bind well with F-, which is beneficial for fluorination reactions. Due to its good catalytic effect, high selectivity, high thermal stability, low toxicity, and recyclability, quaternary phosphonium salt phase transfer catalysts have been widely used in recent years.
Synthesis
7.86 g (0.03 mol) triphenylphosphine was added with 20 ml acetonitrile to a fitted with a condenser tube.
100 ml three-necked flask, nitrogen protection under constant pressure dropwise addition of 8 mL (0.06 mol) bromobutane, reflux stirring reaction 10h, the reaction
After completion, get homogeneous yellow oily liquid, put in the refrigerator to cool, to be precipitated after the white solid, filter out the white solid, with ethyl
Nitrile and ethyl acetate mixed solution recrystallization, and then filtration under reduced pressure, dried in a vacuum drying oven at 60 , obtained 9.22g (0.026mol) butyltriphenylphosphonium chloride, molar yield of 86.7%.
