Taltobulin (trifluoroacetate)
- Product NameTaltobulin (trifluoroacetate)
- CAS228266-41-9
- CBNumberCB42735540
- MFC29H44F3N3O6
- MW587.6713696
- MOL File228266-41-9.mol
Chemical Properties
| storage temp. | Store at -20°C |
| solubility | DMSO : ≥ 39 mg/mL (66.36 mM) |
| form | Solid |
| color | White to off-white |
Taltobulin (trifluoroacetate) Price
| Product number | Packaging | Price | Product description | Buy |
|---|---|---|---|---|
| ChemScene CS-3787 | 5mg | $220 | Taltobulin(trifluoroacetate) 99.96% |
Buy |
| ChemScene CS-3787 | 10mg | $340 | Taltobulin(trifluoroacetate) 99.96% |
Buy |
| ChemScene CS-3787 | 50mg | $950 | Taltobulin(trifluoroacetate) 99.96% |
Buy |
| Crysdot CD31002592 | 5mg | $216 | Taltobulintrifluoroacetate 98+% |
Buy |
| Crysdot CD31002592 | 50mg | $910 | Taltobulintrifluoroacetate 98+% |
Buy |
Taltobulin (trifluoroacetate) Chemical Properties,Usage,Production
Uses
Taltobulin trifluoroacetate (HTI-286 trifluoroacetate), a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Taltobulin trifluoroacetate inhibits the polymerization of purified tubulin, disrupts microtubule organization in cells, and induces mitotic arrest, as well as apoptosis[1].in vivo
Taltobulin (HTI-286; 1.6 mg/kg i.v.) inhibits the growth of human tumor xenografts (e.g., HCT-15, DLD-1, MX-1W, and KB-8-5) in athymic nu/nu female mice[1].
Taltobulin (HTI-286; 3 mg/kg; p.o. gavage) inhibits growth by 97.3 % and 82% in athymic nu/nu female mice with Lox melanoma xenografts and KB-3-1 epidermoid xenograft model, respectively[1].
| Animal Model: | Athymic nu/nu female mice with Lox melanoma model (5-6 weeks of age)[1] |
| Dosage: | 1.6 mg/kg |
| Administration: | Administered i.v.;for 35 days |
| Result: | Growth of Lox tumors was inhibited by 96-98% on day 12 compared with vehicle-treated controls. Growth of KB-8-5 tumors was inhibited by 84% on day 14 compared with vehicle-treated controls. Growth of MX-1W tumors was inhibited by 97% compared with vehicle-treated controls. Growth of DLD-1 and HCT-15 tumors was inhibited by 80 and 66%, respectively. |
IC 50
Traditional Cytotoxic AgentsReferences
[1] Loganzo F, et al. HTI-286, a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Cancer Res. 2003 Apr 15;63(8):1838-45. PMID:12702571Preparation Products And Raw materials
Taltobulin (trifluoroacetate) Suppliers
Global(28)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| +1-781-999-5354; +17819995354 |
marketing@targetmol.com | United States | 32435 | 58 | |
| +86-0371-86658258 +8613203830695 |
laboratory@coreychem.com | China | 30229 | 58 | |
| +86-0917-3909592 +86-13892490616 |
gksales1@gk-bio.com | China | 9209 | 58 | |
| +86-057181025280; +8617767106207 |
sales@molcore.com | China | 49734 | 58 | |
| 571-89925085 | sales@amadischem.com | China | 131957 | 58 | |
| 021-58950125 | info@chemexpress.com | China | 7552 | 61 | |
| 021-58955995 | sales@medchemexpress.cn | United States | 4861 | 58 | |
| 021-65675885 18964387627 |
info@efebio.com | China | 9803 | 58 | |
| 020-61288194 61288195 | 505721671@qq.com | China | 3866 | 58 | |
| 010-60605840 18892239720 |
psaitong@jm-bio.com | China | 12306 | 58 |
View Lastest Price from Taltobulin (trifluoroacetate) manufacturers
PROMPT×
PROMPT
The What'sApp is temporarily not supported in mainland China
The What'sApp is temporarily not supported in mainland China
Cancel
Determine