Preparation
0.41 g of pyridineboronic acid and 0.39 g of pinacol were placed in a 50 mL round-bottom flask, and an appropriate amount of toluene was added as a solvent. The mixture was refluxed. Throughout the process, the evaporated water was continuously released from the system. After 4 hours, the reaction was stopped, and thin-layer chromatography (TLC) was used to check whether the reaction was complete. The round-bottom flask was cooled to room temperature and filtered to obtain 0.67 g of 4-Pyridineboronic acid pinacol ester as a white solid.
Chemical Properties
white to off-white powder
Uses
4-Pyridineboronic Acid Pinacol ester is used in dermatological preparations containing antioxidants and boron compounds for preventing damages to skin caused by peroxides.
Uses
It is employed in the synthesis of new pyridazino[4,5-b]indol-4-ones and pyridazin-3(2H)-one analogs as DYRK1A inhibitors.
