ChemicalBook CAS DataBase List Sarecycline Hydrochloride

Sarecycline Hydrochloride

Product NameSarecycline Hydrochloride
CAS1035979-44-2
CBNumberCB42648136
MFC24H30ClN3O8
MW523.96
MDL NumberMFCD24444565
MOL File1035979-44-2.mol
MSDS FileSDS

Chemical Properties

storage temp.	Store at -20°C
solubility	DMF: 0.25 mg/ml,DMSO: 0.25 mg/ml
form	Solid
color	Light yellow to yellow
InChIKey	APPRLAGZQKOUFL-ZKOKXHCXNA-N
SMILES	O[C@@]12C(C(C(=O)N)=C(O)[C@@H](N(C)C)[C@]1([H])C[C@]1([H])CC3=C(C=CC(O)=C3C(=O)C1=C2O)CN(C)OC)=O.Cl \|&1:1,9,13,16,r\|
FDA UNII	36718856JR
ATC code	J01AA14
UNSPSC Code	51101500
NACRES	NA.21

Safety

Symbol(GHS)
Signal word	Danger
Hazard statements	H360
WGK Germany	WGK 3
Storage Class	11 - Combustible Solids

Sarecycline Hydrochloride Price

Product number	Packaging	Price	Product description	Buy
Cayman Chemical 24685	1mg	$43	P005672 (hydrochloride) ≥98%	Buy
Cayman Chemical 24685	5mg	$191	P005672 (hydrochloride) ≥98%	Buy
Usbiological 465876	5mg	$545	Sarecycline Hydrochloride	Buy
Usbiological 465876	10mg	$842	Sarecycline Hydrochloride	Buy
Biosynth KRB97944	10mg	$618.8	Sarecycline Hydrochloride	Buy

Sarecycline Hydrochloride Chemical Properties,Usage,Production

Uses

Sarecycline Hydrochloride is a substituted tetracycline compound used for treatment of bacterial infections and neoplasms.

Biological Activity

Sarecycline Hydrochloride iinhibits bacterial protein synthesis by binding to the 30S subunit of the bacterial ribosome. Specifically, it binds to the A site of the ribosome and blocks the attachment of aminoacyl-tRNA molecules to the ribosome, which is necessary for the addition of new amino acids to the growing polypeptide chain. This ultimately leads to the inhibition of bacterial protein synthesis and reduction in bacteria th at are associated with acne.

in vivo

Sarecycline hydrochloride (0.33-9 mg/kg; i.v.) show potent activity against S. aureus in a murine neutropenic thigh infection model^[1].
Sarecycline can inhibit S. aureus (PD₅₀=0.25 mg/kg), but has no significant effect on E. coli even at the highest dose (>40 mg/kg) in CD-1 mice model of systemic (intraperitoneal) infection^[6].
Sarecycline (1-150mg/kg; Intraperitoneal injection; Single dose) shows anti-inflammatory activity in Sprague Dawley rats model^[6].

Animal Model:	Female SD-1 mice (A murine neutropenic thigh wound infection model)^[1]
Dosage:	0.33, 1, 3, or 9mg/kg
Administration:	Intravenously
Result:	Achieved a 2-log10 reduction in the bacterial burden in the thigh at a dose comparable to that of doxycycline, with ED50s of 8.23 and 8.32mg/kg, respectively.

Animal Model:	Carrageenan-induced footpad edema male Sprague Dawley rats model^[6]
Dosage:	1 mg/kg, 5 mg/kg ,10 mg/kg, 25 mg/kg, 50 mg/kg, 75 mg/kg,100 mg/kg, 150 mg/kg
Administration:	Intraperitoneal injection (i.p.); Single dose. Before a subplantar injection of sterile 1 mg/0.1 mL carrageenan solution in the right hind paw.
Result:	Reduced inflammation to 55.7% and 53.1%, respectively, at doses of 75 mg/kg and 100 mg/kg compared to baseline.

IC 50

Tetracycline

Sarecycline Hydrochloride synthesis

Preparation Products And Raw materials

Sarecycline Hydrochloride Supplier

Supplier	Tel	Email	Country	ProdList	Advantage
Hubei Tianshu Pharmaceutical Co., Ltd	025-58741518 13327727315	yao_dongyuan@vcarepharmatech.com	China	19	58
ShangHai ChuanQian Chemcial Technique Centre	15869524721	3525679403@qq.com	China	4566	58
Hunan ravel Biotechnology Co.,Ltd	18086085632	435918333@qq.com	China	1727	58
Shanghai Boyle Chemical Co., Ltd.		sales@boylechem.com	China	2915	55
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.	025-66113011 13913916777	cfzhang@aikonchem.com	China	19902	55
Bsisun HK Imoprt And Export Company Limited	+86-18068513926		China	1273	55
Guangzhou Isun Pharmaceutical Co., Ltd	020-39119399 18927568969	isunpharm@qq.com	China	4773	55
AdooQ BioScience, LLC	+1 (866) 930-6790	info@adooq.com	United States	2774	58
GIHI CHEMICALS CO.,LTD	0086-571-86217390	Sales@gihichem.com	China	858	58
AdooQ Bioscience CHINA	025-58849295	info@adooq.cn	China	2981	60