ChemicalBook CAS DataBase List 1035979-44-2

1035979-44-2

Name	P005672 hydrochloride
CAS	1035979-44-2
Molecular Formula	C24H30ClN3O8
MDL Number	MFCD22648366
Molecular Weight	523.963
MOL File	1035979-44-2.mol

Synonyms

CS-267 P005672 PO05672 PO05672 HCl P005672 HCl Sarecycline Sarecycline HCl P0-05672;P0 05672 Sarecycline(P005672) Minocycline Impurity 14 P005672 (hydrochloride) PO05672;SARECYCLINE HCL P005672(SARECYCLINE HCL) Sarecycline (hydrochloride) P005672 HCl (Sarecycline HCl) Sarecycline(P005672 hydrochloride) Minocycline Impurity 14（Sarecycline） (4S,4AS,5aR,12aS)-4-(dimethylamino)-3,10,12,12a-tetrahydroxy-7-((methoxy(methyl)amino)methyl)- (4s,4as,5ar,12ar)-4-(dimethylamino)-1,10,11,12a-tetrahydroxy-7-[[methoxy(methyl)amino]methyl]-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide (4S,4aS,5aR,12aR)-4-(dimethylamino)-1,10,11,12a-tetrahydroxy-7-[[methoxy(methyl)amino]methyl]-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide,hydrochloride (4S,4aS,5aR,12aS)-4-(DiMethylaMino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-7-[(MethoxyMethylaMino)Methyl]-1,11-dioxo-2-naphthacenecarboxaMide hydrochloride 4S,4aS,5aR,12aS)-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-7-[(methoxymethylamino)methyl]-1,11-dioxo-2-naphthacenecarboxamide hydrochloride P005672 HCl

Chemical Properties

storage temp.	Store at -20°C
solubility	DMF: 0.25 mg/ml,DMSO: 0.25 mg/ml
form	Solid
color	Light yellow to yellow
InChIKey	APPRLAGZQKOUFL-ZKOKXHCXNA-N
SMILES	O[C@@]12C(C(C(=O)N)=C(O)[C@@H](N(C)C)[C@]1([H])C[C@]1([H])CC3=C(C=CC(O)=C3C(=O)C1=C2O)CN(C)OC)=O.Cl \|&1:1,9,13,16,r\|

Safety Data

Symbol(GHS)	GHS08
Signal word	Danger
Hazard statements	H360
WGK Germany	WGK 3
Storage Class	11 - Combustible Solids

Hazard Information

Uses

Sarecycline Hydrochloride is a substituted tetracycline compound used for treatment of bacterial infections and neoplasms.

Biological Activity

Sarecycline Hydrochloride iinhibits bacterial protein synthesis by binding to the 30S subunit of the bacterial ribosome. Specificallyit binds to the A site of the ribosome and blocks the attachment of aminoacyl-tRNA molecules to the ribosomewhich is necessary for the addition of new amino acids to the growing polypeptide chain. This ultimately leads to the inhibition of bacterial protein synthesis and reduction in bacteria th at are associated with acne.

in vivo

Sarecycline hydrochloride (0.33-9? mg/kg; i.v.) show potent activity against S. aureus in a murine neutropenic thigh infection model^[1].
Sarecycline can inhibit S. aureus (PD₅₀=0.25 mg/kg), but has no significant effect on E. coli even at the highest dose (>40 mg/kg) in CD-1 mice model of systemic (intraperitoneal) infection^[6].
Sarecycline (1-150mg/kg; Intraperitoneal injection; Single dose) shows anti-inflammatory activity in Sprague Dawley rats model^[6].

Animal Model:	Female SD-1 mice (A murine neutropenic thigh wound infection model)^[1]
Dosage:	0.33, 1, 3, or 9?mg/kg
Administration:	Intravenously
Result:	Achieved a 2-log10 reduction in the bacterial burden in the thigh at a dose comparable to that of doxycycline, with ED50s of 8.23 and 8.32?mg/kg, respectively.

Animal Model:	Carrageenan-induced footpad edema male Sprague Dawley rats model^[6]
Dosage:	1 mg/kg, 5 mg/kg ,10 mg/kg, 25 mg/kg, 50 mg/kg, 75 mg/kg,100 mg/kg, 150 mg/kg
Administration:	Intraperitoneal injection (i.p.); Single dose. Before a subplantar injection of sterile 1 mg/0.1 mL carrageenan solution in the right hind paw.
Result:	Reduced inflammation to 55.7% and 53.1%, respectively, at doses of 75 mg/kg and 100 mg/kg compared to baseline.

IC 50

Tetracycline

Spectrum Detail

Supplier

Hubei Tianshu Pharmaceutical Co., Ltd

Telephone025-58741518 13327727315

Websitehttp://www.tianshupharm.com

ShangHai ChuanQian Chemcial Technique Centre

Telephone 15869524721

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList68594/0_EN.htm

Beijing Jin Ming Biotechnology Co., Ltd.

Telephone010-60605840 15801484223;

Websitehttp://www.jm-bio.com/

Shanghai Boyle Chemical Co., Ltd.

Telephone

Websitehttp://www.boylechem.com

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Telephone025-66113011 13913916777

Websitehttp://www.aikonchem.com/

Bsisun HK Imoprt And Export Company Limited

Telephone+86-18068513926

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList15511/0_EN.htm

Guangzhou Isun Pharmaceutical Co., Ltd

Telephone020-39119399 18927568969

Websitehttp://www.isunpharm.com

GIHI CHEMICALS CO.,LTD

Telephone0086-571-86217390

Websitehttp://www.gihichem.com

AdooQ Bioscience CHINA

Telephone025-58849295 18951903616;

Websitehttp://www.adooq.cn

Credit Asia Chemical Co., Ltd.

Telephone+86 (21) 61124340

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList16523/0_EN.htm

LETOPHARM LIMITED

Telephone+86-21-5821 5861

Websitehttp://www.letopharm.com

Shanghai Lollane Biological Technology Co.,Ltd.

Telephone021-52996696，15000506266 15000506266

Websitehttp://www.bioll.com

DebyeTec.com Inc.

Telephone18086626237 18086626237

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList16955/0.htm

SPIRO PHARMA

Telephone

Websitehttp://www.spiropharma.com.cn

Shanghai YuanYe Biotechnology Co., Ltd.

Telephone 13636370518

Websitehttps://www.shyuanye.com

Cangzhou Enke Pharma-tech Co., Ltd.

Telephone0317-5296180 15533709196

Websitehttp://www.enkepharma.com/

ShangHai Biochempartner Co.,Ltd

Telephone177-54423994 17754423994

Websitehttps://www.biochempartner.com

Shanghai Rechem science Co., Ltd.

Telephone021-31433387 15618786686

Websitehttp://cn.rechemscience.com

1of4

Related Products

Send Inquriy