Uses
Diethyl tert-butylmalonate is used in the preparation of enantiomers of 4-tert-butyl-3-isopropyl-2,6,7-trioxa-1-phosphabicyclo[2.2.2]octane 1-sulfide.
Purification Methods
Dissolve it in Et2O, wash with aqueous NaHCO3, H2O, dry (MgSO4), filter, evaporate and distil the residue. Identify by hydrolysis to the acid and determine the neutralisation equivalent (theor: 80.0). The acid has m 155-157o effervescence [Hauser et al. J Am Chem Soc 64 2715 1942, Bush & Beauchamp J Am Chem Soc 75 2949 1953]. [Beilstein 2 IV 2027.]
