Uses
NC 2300 (VEL-0230)is a selective and orally active cysteine cathepsin inhibitor with the IC50 values of 284, 34.5, and 186 nM for cathepsin B, K, and S, respectively.NC 2300 can be used for study of diseases involving bone mineral disorders[1][2].
References
[1] Aoki T,et al. Cathepsin B, K, and S are expressed in cerebral aneurysms and promote the progression of cerebral aneurysms. Stroke. 2008;39(9):2603-2610. DOI:
10.1161/STROKEAHA.107.513648[2] Hirai T, et al. Cathepsin K is involved in development of psoriasis-like skin lesions through TLR-dependent Th17 activation [published correction appears in J Immunol. 2014 May 15;192(10):4933]. J Immunol. 2013;190(9):4805-4811. DOI:
10.4049/jimmunol.1200901
