221144-20-3

Name	NC 2300
CAS	221144-20-3
Molecular Formula	C14H26NNaO5
Molecular Weight	311.35
MOL File	221144-20-3.mol

Synonyms

NC 2300 VEL 0230 (2S,3S)-3-[[[(1S)-3-Methyl-1-[(2-methylpropoxy)methyl]butyl]amino]carbonyl]-2-oxiranecarboxylic acid sodium salt (1:1)

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Hazard Information

Uses

NC 2300 (VEL-0230)is a selective and orally active cysteine cathepsin inhibitor with the IC50 values of 284, 34.5, and 186 nM for cathepsin B, K, and S, respectively.NC 2300 can be used for study of diseases involving bone mineral disorders[1][2].

References

[1] Aoki T,et al. Cathepsin B, K, and S are expressed in cerebral aneurysms and promote the progression of cerebral aneurysms. Stroke. 2008;39(9):2603-2610. DOI:10.1161/STROKEAHA.107.513648
[2] Hirai T, et al. Cathepsin K is involved in development of psoriasis-like skin lesions through TLR-dependent Th17 activation [published correction appears in J Immunol. 2014 May 15;192(10):4933]. J Immunol. 2013;190(9):4805-4811. DOI:10.4049/jimmunol.1200901

Supplier

Alpha Biopharmaceuticals Co., Ltd

Telephone0411-39042497

Websitehttp://alphabiopharm.com/?reqp=1&reqr=

Nextpeptide Inc

Telephone+86-0571-81612335 +8613336028439

Websitehttp://www.nextpeptide.com/

TargetMol Chemicals Inc.

Telephone4008200310 15002144251

Websitehttps://www.targetmol.cn/

Suzhou Meishi Biotechnology Co., Ltd.

Telephone 1173954148q

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList1822805/0_EN.htm

Shandong Ziyi Pharmaceutical Co., Ltd.

Telephone 17860786593

Website

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