Chemical Properties
WHITE CRYSTALLINE POWDER
Uses
3-Aminopropionitrile fumarate salt has been used as a lysyl oxidase (LOX) inhibitor:
- to inhibit collagen cross-linking during microtissue formation and culture
- in LIM domain only 1 (LMO1)- or vector-expressing BE2C neuroblastoma cell line in transwell migration and invasion assay
- in lysyl oxidase (LOX) activity assay
- to study requirement of LOX activity for inducing hypoxia-inducible factor (HIF)2A-dependent stiffness in mouse organoids
Definition
ChEBI: A fumarate salt prepared from beta-aminopropionitrile by reaction of one molecule of fumaric acid for every two molecules of beta-aminopropionitrile.
Biochem/physiol Actions
3-Aminopropionitrile (β-Aminopropionitrile (BAPN)) functions as an irreversible inhibitor of lysyl oxidase (LOX), an enzyme involved in collagen cross-linking.
Safety Profile
Moderately toxic by ingestion and intraperitoneal routes. An experimental teratogen. When heated to decomposition it emits toxic fumes of NO, and CN-. See also NITRILES.
