Chemical Properties
Octyldodecanol occurs as a clear, colorless, or yellowish, oily liquid.
Chemical Properties
2-Octyl-1-dodecanol is clear, colourless or yellowish, oily liquid.
Uses
2-Octyl-1-dodecanol have been used as a emulsion stabilizer for polymer matrix patches.
Uses
2-Octyldodecane-1-ol have been used as a emulsion stabilizer for polymer matrix patches.
Uses
2-Octyl-1-dodecanol may be used to investigate its interaction with the hexameric capsules of resorcin[4]arene. It has been used as diluent in a extractant screening study for the recovery of putrescine (butylene-1,4-diamine, BDA) and cadaverine (pentylene-1,5-diamine, PDA) from aqueous solutions (fermentation broths) by liquid-liquid extraction.
Production Methods
2-Octyl-1-dodecanol is produced by the condensation of two molecules of decyl alcohol. It also occurs naturally in small quantities in plants.
General Description
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Pharmaceutical Applications
Octyldodecanol is widely used in cosmetics and pharmaceutical
applications as an emulsifying and opacifying agent. It is primarily
used in topical applications because of its lubricating and emollient
properties.
Octyldodecanol has been used in the preparation of oil/water
microemulsions investigated as the vehicle for the dermal administration
of drugs having no or low skin penetration.Octyldodecanol
has also been evaluated as a solvent for naproxen when
applied topically.Studies of estimated permeability coefficient
suggest that octyldodecanol could be a potential dermal permeation
enhancer.
Safety Profile
An eye and severe skin irritant.When heated to decomposition it emits acrid smoke andirritating vapors.
Safety
Octyldodecanol is widely used in cosmetics and topical pharmaceutical
formulations, and is generally regarded as nontoxic and
nonirritant at the levels employed as an excipient.
In acute oral toxicity studies in rats fed 5 g/kg of undiluted
octyldodecanol, no deaths were observed.In an acute dermal
toxicity study, intact and abraded skin sites of guinea pigs were
treated with 3 g/kg of undiluted octyldodecanol under occlusive
patches; no deaths occurred and no gross skin lesions were
observed.Octyldodecanol caused either no ocular irritation or
minimal, transient irritation in the eyes of rabbits.However, some
sources describe undiluted octyldodecanol as an eye and severe skin
irritant.
storage
The bulk material should be stored in a well-closed container in a
cool, dry place, protected from light. In the original unopened
container, octyldodecanol can be stored for 2 years protected from
moisture at below 30°C.
Incompatibilities
2-Octyl-1-dodecanol is generally compatible with most materials encountered in cosmetic and pharmaceutical formulations.
Regulatory Status
Included in the FDA Inactive Ingredients Database (topical,
transdermal, and vaginal preparations). Included in nonparenteral
medicines licensed in the UK. Included in the Canadian List of
Acceptable Non-medicinal Ingredients.
