Chemical Properties
White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Aster tataricus, Bambusa chinensis, and Taraxacum officinale.
Uses
β-Taraxerol has potential application against novel coronavirus SARS-CoV-2, in silico approach to assess the inhibitory potential.
Definition
ChEBI: A pentacyclic triterpenoid that is oleanan-3-ol lacking the methyl group at position 14, with an alpha-methyl substituent at position 13 and a double bond between positions 14 and 15.
Synthesis
The use of efficient extraction method of dandelion root in dandelion racemosanol extraction and separation, including the following steps: (1) reflux method of dandelion root to 30% ~ 95% ethanol solution extraction 1 ~ 3 times, each time 1 ~ 3 hours, the extraction conditions preferably 75% of the ethanol solution extraction three times, each time 1 hour; (2) the combined extracts, concentrated under reduced pressure to the no-alcohol flavor, plus ethanol precipitation of polysaccharides, peptides, etc. (3) and then extracted with an equal volume of ethyl acetate or n-butanol for three times, the extract is concentrated to get the extract; (4) the extract is purified by silica gel column chromatography, reversed-phase column chromatography and other methods. Silica gel column chromatography: generally to petroleum ether - ethyl acetate or chloroform - methanol - water mixed solvent system gradient elution, reversed-phase silica gel column chromatography: commonly used C8 or C18, to gradient methanol and water gradient elution to get the compound dandelion Sai alcohol.
in vivo
Taraxerol (5 and 10mg/kg; i.p.) attenuates carrageenan induced paw edema. The effect of taraxerol at the dose of 5mg/kg is found to be significant (p<0.05) only after 4h of carrageenan treatment[2].
target
NO | PGE | TNF-α | IL Receptor | NF-kB | TGF-β/Smad | Akt
