Description
CP 47,497 is a monophenol cannabimimetic compound that binds the central cannabinoid (CB
1) receptor with a K
i value of 2.2 nM. It is equivalent in analgesic potency to Δ
9-
THC and exhibits other CB biological activities as well.
Chemical Properties
White Solid
Uses
A cannabinoid receptor ligand.
Definition
ChEBI: Phenol, 5-(1,1-dimethylheptyl)-2-[(1r,3s)-3-hydroxycyclohexyl]- is a ring assembly and an alkylbenzene.
Biological Activity
Potent CB 1 receptor agonist (K i = 2.2 nM). Display 3-28-fold > potency than Δ 9 -THC . Exhibits analgesic, motor depressant, anticonvulsant and hypothermic effects in vivo .
References
[1] JOHN W. HUFFMAN . Synthesis and pharmacology of 1-deoxy analogs of CP-47,497 and CP-55,940[J]. Bioorganic & Medicinal Chemistry, 2008, 16 1: Pages 322-335. DOI:
10.1016/j.bmc.2007.09.033[2] L S MELVIN. Structure-activity relationships for cannabinoid receptor-binding and analgesic activity: studies of bicyclic cannabinoid analogs.[J]. Molecular Pharmacology, 1993, 44 5: 1008-1015.
