GUANOSINE 5'-DIPHOSPHATE SODIUM SALT

Uses

Guanosine 5′-diphosphate sodium salt has been used:

• in GTP-γ-35S functional assays
• in Y1 agonist-stimulated [35S]- guanosine-5′-O-(3-thio)triphosphate (GTPγS) functional binding
• in the expression and purification of recombinant proteins

Biochem/physiol Actions

Guanosine 5′-diphosphate (GDP) is the diphosphate nucleoside of the purine guanine. GDP and GTP are involved in and may be used to study cell signaling via G-coupled protein receptors (GCPR) and guanine nucleotide exchange factors (GEF) and a variety of GTPases.