Description
7α-hydroxy-4-Cholesten-3-one is a metabolite of 7α-hydroxy cholesterol and an intermediate in the biosynthesis of bile acids. Plasma levels of 7α-hydroxy-4-cholesten-3-one positively correlate with the rate of bile acid synthesis in humans and are increased in patients following ileal resection.
Chemical Properties
White Solid
Uses
7α-Hydroxy-4-cholesten-3-one is a metabolite of Cholesterol (C432501).
Definition
ChEBI: A cholestanoid consisting of a cholesterol core having an oxo group at the 3-position, a C2C bond at the 4,5-position and an alpha-hydroxy group at the 7-position.
References
[1] RUSSELL D W. The enzymes, regulation, and genetics of bile acid synthesis.[J]. Annual review of biochemistry, 2003, 72: 137-174. DOI:
10.1146/annurev.biochem.72.121801.161712[2] M. AXELSON J. S A Aly. Levels of 7α-hydroxy-4-cholesten-3-one in plasma reflect rates of bile acid synthesis in man[J]. FEBS Letters, 1988, 239 2: Pages 324-328. DOI:
10.1016/0014-5793(88)80944-x