Synthesis
Add 1400L of tert-butyl acetate, 105KG of glycine to 2000L reaction tank, and add 180KG of perchloric acid at a uniform rate. Reaction at 0-10 about 48-72 hours, the reaction process TLC to monitor the reverse situation, to be glycine reaction more than 90%, with 4 N sodium hydroxide aqueous solution to adjust the PH6.5-7.5, separated from the organic layer, the aqueous layer continues to be extracted with tert-butyl acetate, to be basically extracted to 95% of the products of water, combined with all the product layer, to be extracted to 95% of the product, and the water layer, to be extracted to 95% of the product. After 95% of the product was extracted, all the product layers were combined and washed with brine to TLC pure, then 1500L of tert-butyl glycinate / tert-butyl ethyl ester solution was obtained, tert-butyl glycinate was concentrated and recycled to obtain tert-butyl glycinate 180KG, 100L of ethyl ethyl ester was added, and the product was passed through the HCl to PH0.5, then stirred to cool and cold crystallize, and centrifugally washed to obtain tert-butyl glycinate hydrochloride 182KG.
