Chemical Properties
HCFC 133a is odorless with poor warning properties.
Uses
HCFC133a is a nonisolated intermediate in the production of
halothane.
Definition
ChEBI: 2-Chloro-1,1,1-trifluoroethane is an organofluorine compound.
Synthesis Reference(s)
Journal of the American Chemical Society, 70, p. 758, 1948
DOI: 10.1021/ja01182a096
General Description
2-CHLORO-1,1,1-TRIFLUOROETHANE is a colorless, odorless gas. 2-CHLORO-1,1,1-TRIFLUOROETHANE is shipped as a liquid under its own vapor pressure. Contact with the liquid may cause frostbite to unprotected skin. 2-CHLORO-1,1,1-TRIFLUOROETHANE can asphyxiate by the displacement of air. Exposure of the container to fire or heat can cause 2-CHLORO-1,1,1-TRIFLUOROETHANE to rupture violently and rocket.
Reactivity Profile
2-CHLORO-1,1,1-TRIFLUOROETHANE is chemically inert in many situations, but can react violently with strong reducing agents such as the very active metals and the active metals. Undergoes oxidation with strong oxidizing agents and under extremes of temperature.
Health Hazard
Vapors may cause dizziness or asphyxiation without warning. Vapors from liquefied gas are initially heavier than air and spread along ground. Contact with gas or liquefied gas may cause burns, severe injury and/or frostbite. Fire may produce irritating, corrosive and/or toxic gases.
Fire Hazard
Some may burn but none ignite readily. Containers may explode when heated. Ruptured cylinders may rocket.
Safety Profile
A poison by inhalation.
Experimental reproductive effects.
Questionable carcinogen with experimental
carcinogenic data. When heated to
decomposition it emits toxic fumes of F-.
Carcinogenicity
HCFC 133a was evaluated in a
carcinogenesis screening study using Wistar-derived
rats. The rats were given daily intubations of 300mg HCFC
of body weight in corn oil for 52 weeks and held for a total of
125 weeks. In the males, there was a reduction in body
weight gain and testicular size, also there was an increase
in Leydig cell tumors and arrest of spermatogenesis.
In the females, there was an increased incidence of uterine
carcinomas.
