Synthesis
Weighed diisopropyl 3,3’-dithiodipropionate (1.15 mol), anhydrous Na2SO3106.5 g (0.845 mol), water 296.0 g in a 1000 mL flask, water bath warmed to 50 C to 55 C, passed H2S (about 0.025 L/min) for a total of 10 h. The reaction was carried out at atmospheric pressure for 1 h (calculated from the After the reaction was carried out at atmospheric pressure for 1h (counting from the start of the passage of H2S), Na2SO310.0g was added every half an hour, totaling 80.0g (0.635mol) for 8 times. After the passage of H2S to stop, holding 15min, pumping and filtration of the reaction solution, filtrate stratification; the oil layer washed, and then stratification, the oil layer with a circulating pump distillation under reduced pressure, that is, 3-mercaptopropionic acid isopropyl ester.
