Chemical Properties
Propyleneimine is a fuming, colorless, oily
liquid with a strong ammonia-like odor.
Chemical Properties
colourless oily fuming liquid
Uses
The renal papillary toxin.
Uses
Intermediate in production of polymers,
coatings, adhesives, textiles, and paper
finishes.
Definition
ChEBI: 2-Methylaziridine is a member of aziridines.
General Description
A clear colorless liquid with an ammonia-like odor. Flash point 25°F. Toxic by ingestion, inhalation and through skin absorption. Less dense than water. Vapors are heavier than air. Produces toxic oxides of nitrogen during combustion. Under prolonged exposure to fire or heat the containers may rupture violently and rocket. Used as an organic intermediate.
Air & Water Reactions
Highly flammable. Soluble in water. Reacts slowly and non hazardously with water to form propanolamine or methylethanolamine.
Reactivity Profile
PROPYLENEIMINE, [INHIBITED] is subject to violent polymerization on contact with an acid. (The inhibitor is intended to prevent polymerization). Incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated in combination with strong reducing agents, such as hydrides.
Hazard
Flammable, dangerous fire risk. Toxic by
ingestion, inhalation, and skin absorption. Upper
respiratory tract irritant and kidney damage. Possi-
ble carcinogen.
Health Hazard
Toxic after acute exposure. Can severely irritate eyes, skin, and lungs.
Fire Hazard
Chemical is extremely flammable; vapors are heavier than air. Toxic oxides of nitrogen are produced during combustion. Avoid acids, strong oxidizers. Thermally unstable. Hazardous polymerization may occur. Contact with acid promotes violent polymerization.
Safety Profile
Confirmed carcinogen
with experimental carcinogenic data. Poison
by ingestion and skin contact. Moderately
toxic by inhalation. Mutation data reported.
Severe eye irritant. Implicated as a brain
carcinogen. A flammable liquid and very
dangerous fire hazard when exposed to heat
or flame; can react vigorously with oxidizing
materials. Polymerizes explosively on
exposure to acids or acid fumes. A storage
hazard. When heated to decomposition it
emits toxic fumes of NOx.
Potential Exposure
Propyleneimine is used in the modifi-
cation of latex surface coating resins; in the production of
polymers for use in the paper and textile industries as coat-
ings and adhesives.
Carcinogenicity
2-Methylaziridine is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.
Shipping
UN1921 Propyleneimine, stabilized, Hazard
Class: 3; Labels: 3-Flammable liquid, 6.1-Poisonous
materials.
Incompatibilities
Vapors or liquid form explosive mixture
with air. Incompatible with oxidizers (chlorates, nitrates,
peroxides, permanganates, perchlorates, chlorine, bromine,
fluorine, etc.); contact may cause fires or explosions. Keep
away from alkaline materials, strong bases, strong acids,
oxoacids, epoxides, water, carbonyl compounds; quinones,
sulfonyl halides. May explode in heat. Subject to violent
polymerization in contact with acids. Hydrolyzes in water
to form methylethanolamine.
Toxics Screening Level
The initial threshold screening level (ITSL) for 1,2-propylenimine is 5 μg/m3 with an 8-hour averaging time.
Waste Disposal
Consult with environmental
regulatory agencies for guidance on acceptable disposal
practices. Generators of waste containing this contaminant
(≥100 kg/mo) must conform with EPA regulations
governing storage, transportation, treatment, and waste
disposal. Controlled incineration (incinerator equipped
with a scrubber or thermal unit to reduce nitrogen oxides
emissions).
Description
GSTP1 Human Recombinant fused with 36 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 246 amino acids
(1-210 a.a.) And having a molecular mass of 27.4kDa.
The GSTP1 is purified by proprietary chromatographic techniques.
Background
GSTP1 is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are believed to function in xenobiotic metabolism and have a part in susceptibility to cancer, and other diseases. GSTP1 is a glutathione S-transferase belonging to the pi class. GST family enzymes play a significant role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based upon the biochemical, immunologic and structural properties of the soluble GSTs they are grouped into 4 main classes: alpha, mu, pi, and theta. The GSTP1 enzyme acts by catalyzing the reaction of glutathione with an acceptor molecule to form a Sulfur-substituted glutathione. The reactions employing glutathione contribute the transformation of a broad range of electrophiles, including reactive products of lipid, protein, carcinogens, therapeutic drugs, environmental toxins, and products of oxidative stress.
The GSTP1 inactivation through CpG hypermethylation is frequent in pituitary adenomas and may be a factor in aggressive pituitary tumor behavior. GSTP1 is may be a transcriptional target of the p53 tumor suppressor gene. Single-nucleotide polymorphism in GSTP1 is linked to modified protein binding, which influence GSTP1's contribution to carcinogen and drug metabolism, and possibly disease pathogenesis and/or drug response. GST-pi might have central roles in proliferation of androgen-independent human prostate cancer cells.
