Delpazolid

Product NameDelpazolid
CAS1219707-39-7
CBNumberCB33357946
MFC14H17FN4O3
MW308.31
EINECS-0
MDL NumberMFCD29918770
MOL File1219707-39-7.mol

Chemical Properties

Boiling point	481.8±55.0 °C(Predicted)
Density	1.44±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO:30.0(Max Conc. mg/mL);97.3(Max Conc. mM)
form	A crystalline solid
pka	14.05±0.10(Predicted)
color	White to off-white
FDA UNII	43EP6XV33E

Delpazolid Price

Product number	Packaging	Price	Product description	Buy
Cayman Chemical 25532	1mg	$44	Delpazolid	Buy
Cayman Chemical 25532	5mg	$193	Delpazolid	Buy
Cayman Chemical 25532	10mg	$341	Delpazolid	Buy
Cayman Chemical 25532	25mg	$745	Delpazolid	Buy
AK Scientific 2814DF	25mg	$927	Delpazolid	Buy

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Delpazolid Chemical Properties,Usage,Production

Description

Delpazolid is an oxazolidinone antibiotic. It is active against a wide range of Gram-positive bacterial clinical isolates, including resistant strains of several species, such as methicillin-resistant S. aureus (MRSA), methicillin-resistant coagulase-negative staphylococci (MRCNS), and penicillin-resistant S. pneumoniae (MICs = 0.125-4 μg/ml). Delpazolid increases survival in mouse models of systemic MRSA, E. faecalis, S. pneumoniae, and H. influenzae infection (ED₅₀s = 2.96, 4.53, 2.28, and 9.96 mg/kg, respectively).

Uses

Delpazolid is a novel oxazolidinone antibiotic agent which can inhibit the growth of MSSA and MRSA with a MIC90 of 2 μg/mL for both of them.

in vivo

When administered orally, Delpazolid (LCB01-0371) shows potent protective effects against systemic infections caused by Gram-positive and Gram-negative bacteria. Against infection caused by S. aureus Giorgio (MSSA), the ED₅₀ of Delpazolid is 4.53 mg/kg of body weight. Against S. aureus p125 (MRSA), the ED₅₀ of Delpazolid is 2.96 mg/kg^[1]. When Delpazolid (LCB-0371) is administered at 100 mg/kg daily (by gavage), the colony-forming unit (CFU) counts tend to be decreased in the lungs of mice at 7 days after infection^[2].

IC 50

Oxazolidinone

References

[1] Jeong JW, et al. In vitro and in vivo activities of LCB01-0371, a new oxazolidinone. Antimicrob Agents Chemother. 2010 Dec;54(12):5359-62. DOI:10.1128/AAC.00723-10
[2] Kim TS, et al. Activity of LCB01-0371, a Novel Oxazolidinone, against Mycobacterium abscessus. Antimicrob Agents Chemother. 2017 Aug 24;61(9). DOI:10.1128/AAC.02752-16

Delpazolid synthesis

1334167-72-4

60456-26-0

1219707-39-7

More Synthesis

Preparation Products And Raw materials

Raw materials

ethyl (3-fluoro-4-(1-methyl-5,6-dihydro-1,2,4-triazin-4(1H)-yl)phenyl)carbamate(WXG00214)
2-fluoro-N-(2-(1-methylhydrazinyl)ethyl)-4-nitroaniline(WXG00212)
3-FLUORO-4-(1-METHYL-5,6-DIHYDRO-1H-[1,2,4]TRIAZIN-4-YL)-PHENYLAMINE(WXG00213)
1334167-59-7
4-(2-fluoro-4-nitrophenyl)-1-methyl-1,4,5,6-tetrahydro-1,2,4-triazine

(R)-Glycidyl butyrate
Formaldehyde
3,4-Difluoronitrobenzene

1of2

Delpazolid Supplier

Global(86)Suppliers

Region

China 78 India 1 United States 7

Clear All Done

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19552	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29798	58
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32435	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6312	58
Baoji Guokang Healthchem co.,ltd	+8615604608665 15604608665	dominicguo@gk-bio.com	CHINA	9414	58
Guangzhou TongYi biochemistry technology Co.,LTD	+8613073028829	tongyibiochem@163.com	China	2995	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
TargetMol Chemicals Inc.	+1-781-999-5354;	support@targetmol.com	United States	39035	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20134	58