Uses
Tedizolid-13C,d3 is the 13C- and deuterium labeled Tedizolid. Tedizolid (TR 700; Torezolid; DA-7157) is a novel oxazolidinone, acting through inhibition of bacterial protein synthesis by binding to 23S ribosomal RNA (rRNA) of the 50S subunit of the ribosome.
References
[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223. DOI:
10.1080/02688697.2018.1500521[2] Choi S, et al.
Activity of Tedizolid Phosphate (TR-701) in Murine Models of Infection with Penicillin-resistant and Penicillin-sensitive Streptococcus pneumoniae.
Antimicrob Agents Chemother. 2012 Jun 19. DOI:
10.1128/AAC.00346-12[3] RONDA SCHAADT. In vitro activity of TR-700, the active ingredient of the antibacterial prodrug TR-701, a novel oxazolidinone antibacterial agent.[J]. Antimicrobial Agents and Chemotherapy, 2009, 53 8: 3236-3239. DOI:
10.1128/aac.00228-09[4] WEON BIN IM . Discovery of torezolid as a novel 5-hydroxymethyl-oxazolidinone antibacterial agent[J]. European Journal of Medicinal Chemistry, 2011, 46 4: Pages 1027-1039. DOI:
10.1016/j.ejmech.2011.01.014
