PALLADIUM (I) TRI-TERT-BUTYLPHOSPHINE BROMIDE

Reactions

• Palladium catalyst for rapid room temperature alkylation of unactivated hindered aryl bromides with arylboronic acids.
• Aryl bromide - silyl ketene acetal coupling.
• Catalyst for intermolecular α-arylation of zinc amide enolates.
• Catalyst for α-vinylation of carbonyl compounds.
• Catalyst for thiol coupling of heteroaromatic aryl bromides.

Chemical Properties

Greenish blue

Uses

Coupling reactions. Will activate aryl chloride and sterically hindered or electron rich aryl/vinyl bromides and iodides. Especially active in difficult aminations.Di-μ-bromobis(tri-tert-butylphosphine)dipalladium(I) is used as a catalyst for Suzuki coupling, Negishi coupling and Buchwald-hartwig amination reactions. It is used as a catalyst for C-C, C-N and C-S bond formation, gamma-arylation of alfa,beta-unsaturated esters and diastereoselective arylation of 4-substituted cyclohexyl esters. It is also involved in aromatic halide substitution reactions.