Synthesis
To 2-bromothiophene (0.489 g, 3 mmol) and 4-formylphenylboronic acid (0.60 g, 4 mmol), K2CO3 (0.696 g, 1 N) and N,N-dimethylformamide (20 mL) were added in a 100 mL three-neck flask. After stirring and mixing under N2 protection for 30 min, tetrakis(triphenylphosphine)palladium (0.115 g, 0.1 mmol) was added. The reaction mixture was stirred at 90 °C for 6 hours. After completion of the reaction, it was naturally cooled to room temperature and the crude product was dissolved in dichloromethane and washed with 100 mL of water. The organic layer was dried with anhydrous MgSO4 to remove water. The final product was purified by recrystallization from ethyl acetate to give 0.46 g of yellow solid in 89% yield.
References
[1] Patent: CN108586438, 2018, A. Location in patent: Paragraph 0040; 0056-0058; 0062
[2] Molecules, 2017, vol. 22, # 3,
[3] Organic Letters, 2017, vol. 19, # 7, p. 1610 - 1613
[4] Patent: KR2017/124005, 2017, A. Location in patent: Paragraph 0206
