MPS1-IN-3

Uses

Mps1-in-3 is a potent and selective Monopolar Spindle 1(MPS1) Inhibitor.

Biological Activity

Mps1 mediates phosphorylation of kinetochore scaffold 1.', 'Mps1-IN-3 is an inhibitor of Monopolar spindle 1 (MPS1, also known as TTK), a Dual-specificity kinase required for spindle pole body duplication and spindle checkpoint function. Mps1-IN-3 inhibited Mps1 kinase activity with an IC50 value of 50 nM inhibited the proliferation of U251 glioblastoma cells as determined by cell counting with an IC50 value of approximately 5 μM, and sensitized glioblastoma cells to vincristine in orthotopic mouse models.