1609584-72-6

Mps1-in-3 is a potent and selective Monopolar Spindle 1(MPS1) Inhibitor.

Mps1 mediates phosphorylation of kinetochore scaffold 1.''Mps1-IN-3 is an inhibitor of Monopolar spindle 1 (MPS1also known as TTK)a Dual-specificity kinase required for spindle pole body duplication and spindle checkpoint function. Mps1-IN-3 inhibited Mps1 kinase activity with an IC50 value of 50 nM inhibited the proliferation of U251 glioblastoma cells as determined by cell counting with an IC50 value of approximately 5 μMand sensitized glioblastoma cells to vincristine in orthotopic mouse models.

Mps1: 50 nM (IC₅₀)

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