Description
5(Z),8(Z),14(Z)-
Eicosatrienoic acid is a polyunsaturated fatty acid that can be a substrate for 5-
lipoxygenase (5-
LO). 5-
LO from RBL-
1 cells converts this fatty acid to 5-
hydroxy-
6,8,14-
eicosatrienoic acid and 5-
hydroperoxy-
6,8,14-
eicosatrienoic acid. Due to the lack of a double bond at C-
11, this particular fatty acid cannot be used in leukotriene A formation.
1
Definition
ChEBI: All-cis-icosa-5,8,14-trienoic acid is an icosatrienoic acid with three cis-double bonds at positions 5, 8 and 14.
References
1. Wei, Y., Evanst, R.W., Morrison, A.R., et al.
Double bond requirement for the 5-lipoxygenase pathway Prostaglandins 29(4),537-545(1985).
