5,8,11-Eicosatrienoic-5,6,8,9,11,12-d6 acid, (5Z,8Z,11Z)-

Description

5(Z),8(Z),11(Z)-Eicosatrienoic Acid-d₆ contains six deuterium atoms at the 5, 6, 8, 9, 11, and 12 positions. It is intended for use as an internal standard for the quantification of 5(Z),8(Z),11(Z)-eicosatrienoic acid by GC- or LC-mass spectrometry. Eicosatrienoic acid accumulates in the tissues of animals fed diets deficient in both ω-3 and ω-6 fatty acids. It can be converted to 3-series cysteinyl-leukotrienes but cannot serve as a COX substrate.¹ The kidneys from essential fatty acid deficient rats are less immunogenic when transplanted, and the metabolites of eicosatrienoic acid are believed to play a role in altering the immune status of these organs.²

References

1. Lefkowith, J.B. Essential fatty acid deficiency: Probing the role of arachidonate in biology Adv. Prostaglandin Thromboxane Leukot. Res. 20,224-231(1990).
2. Schreiner, G.F., Flye, W., Brunt, E., et al. Essential fatty acid depletion of renal allografts and prevention of rejection Science 240,1032-1033(1988).