Uses
[Ala107]MBP(104-118) is an noncompetitive peptide inhibitors of protein kinase C (PKC), with IC50s ranging from 46-145 μM[1].
Biological Activity
[ala107]-mbp (104-118) is a non-competitive inhibitor of pkc and synthetic peptide analog of bovine myelin basic protein (mbp) with ic50 value of 46 - 145 mm.1. substrate specificity of phospholipid/ca2+ dependent protein kinase as probed with synthetic peptide fragments of the bovine myelin basic protein. turner et al. j.biol.chem., 1985;260:115032. synthetic myelin basic protein peptide analogs are specific inhibitors of phospholipid/calcium-dependent protein kinase (protein kinase c). su et al. biochem.biophys.res.commun., 1986;134:78
Biochem/physiol Actions
[Ala107]-Myelin Basic Protein Fragment 104-118 is an inhibitor of protein kinase C.
IC 50
PKC: 46-145 μM (IC
50)
References
[1] Su HD, et, al. Synthetic myelin basic protein peptide analogs are specific inhibitors of phospholipid/calcium-dependent protein kinase (protein kinase C). Biochem Biophys Res Commun. 1986 Jan 14; 134(1): 78-84. DOI:
10.1016/0006-291x(86)90529-2
