Description
Colletodiol is a fungal metabolite that has been found in
D. grovesii and has immunosuppressant and antiviral activities. It inhibits concanavalin A- or LPS-induced proliferation of isolated mouse splenocytes (IC
50s = 12 and 5 μg/ml, respectively). Colletodiol inhibits influenza A viral replication in HeLa-IAV-Luc cells.
Uses
Colletodiol is a metabolite of Chaetomium funicola and an inhibitor of influenza A virus. Colletodiol can be used to synthesize Grahamimycin A and colletol.
References
[1] H. FUJIMOTO. Immunosuppressive Components from an Ascomycete, Diplogelasinospora grovesii[J]. ChemInform, 1998, 61 1. DOI:
10.1002/chin.199837278[2] WENBIN LAI;Xin Y;Shixiong Wang. [Colletodiol inhibits the replication of influenza A virus WSN/H1N1 by reducing the activity of viral RNA polymerase].[J]. Journal of Microbiology, 2013, 53 12: 1334-1339.
