Chemical Properties
Colorless block crystal (acetone), melting point 166 ~ 168℃, soluble in benzene, chloroform and alcohols and other organic solvents.
Biological Activity
Humantenmine, an alkaloid isolated from Chinese nematode, has potential for pain and rheumatoid arthritis.
in vitro
Humantenmine (HMT) decreases the 14-day survival rate of the mice to 17% after they are intragastrically treated with HMT, along with hepatic injury and increasing alanine aminotransferase (ALT)/aspartate aminotransferase (AST) levels. CYP3A4/5 mediates the metabolism and detoxification of HMT.
