82354-38-9

Colorless block crystal (acetone), melting point 166 ~ 168℃, soluble in benzene, chloroform and alcohols and other organic solvents.

Humantenmine, an alkaloid isolated from Chinese nematode, has potential for pain and rheumatoid arthritis.

Humantenmine (HMT) decreases the 14-day survival rate of the mice to 17% after they are intragastrically treated with HMT, along with hepatic injury and increasing alanine aminotransferase (ALT)/aspartate aminotransferase (AST) levels. CYP3A4/5 mediates the metabolism and detoxification of HMT.

P450 (e.g. CYP17)