ChemicalBook CAS DataBase List 27409-30-9

27409-30-9

Name	PICROSIDE I
CAS	27409-30-9
EINECS(EC#)	248-445-1
Molecular Formula	C24H28O11
MDL Number	MFCD00017720
Molecular Weight	492.47
MOL File	27409-30-9.mol

Synonyms

PICROSIDE I Picroside-Ⅰ AMphicoside I Amphicoside Ⅰ PICOLINIC ACID(P) Other Cas No, 76248-14-1 β-D-Glucopyranoside, 1a,1b,2,5a,6,6a-hexahydro- Picroside I, 98%, from Picrorhiza scrophulariiflora Pennel 6-hydroxy-1a-(hydroxymethyl)oxireno[4,5]cyclopenta[1,2-c]pyran-2-yl,6-(3-phenyl-2-propenoate), [1aS-[1aα,1bβ,2β(E),5aβ,6β,6aα]]- (1aS,1bS,2S,5aR,6S,6aS)-1a,1b,2,5a,6,6a-Hexahydro-6-hydroxy-1a-(hydroxymethyl)oxireno[4,5]cyclopenta[1,2-c]pyran-2-yl-β-D-glucopyranoside 6-[(2E)-3-phenyl-2-propenoate] β-D-Glucopyranoside, (1aS,1bS,2S,5aR,6S,6aS)-1a,1b,2,5a,6,6a-hexahydro-6-hydroxy-1a-(hydroxymethyl)oxireno[4,5]cyclopenta[1,2-c]pyran-2-yl, 6-[(2E)-3-phenyl-2-propenoate] (1aS,1bS,2S,5aR,6S,6aS)-6-Hydroxy-1a-(hydroxymethyl)-1a,1b,2,5a,6,6a-hexahydrooxireno[4,5]cyclopenta[1,2-c]pyran-2-yl 6-O-[(2E)-3-phenyl-2-propenoyl]-beta-D-glucopyranoside β-d-Glucopyranoside, 1a,1b,2,5a,6,6a-hexahydro-6-hydroxy-1a-(hydroxymethyl)oxireno[4,5]cyclopenta[1,2-c]pyran-2-yl, 6-(3-phenyl-2-propenoate), [1aS-[1aα,1bβ,2β(E),5aβ,6β,6aα]]- [1aS-[1aalpha,1bbeta,2beta(E),5abeta,6beta,6aalpha]]-1a,1b,2,5a,6,6a-Hexahydro-6-hydroxy-1a-(hydroxymethyl)oxireno[4,5]cyclopenta[1,2-c]pyran-2-yl 6-(3-phenyl-2-propenoate) beta-D-glucopyranoside beta-d-Glucopyranoside, 1a,1b,2,5a,6,6a-hexahydro-6-hydroxy-1a-(hydroxymethyl)oxireno[4,5]cyclopenta[1,2-c]pyran-2-yl, 6-(3-phenyl-2-propenoate), [1aS-[1aalpha,1bbeta,2beta(E),5abeta,6beta,6aalpha]]-

Chemical Properties

Boiling point	778.6±60.0 °C(Predicted)
density	1.56±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	ethanol: soluble1mg/mL, clear, colorless
form	powder
pka	12.70±0.70(Predicted)
color	White
Major Application	metabolomics vitamins, nutraceuticals, and natural products
InChIKey	BSYHSWKTXMTFNF-NTLZGZQOSA-N
SMILES	[C@]12(CO)O[C@H]1[C@H]([C@]1([H])C=CO[C@@H](O[C@H]3[C@H](O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@]21[H])OC(=O)/C=C/C1=CC=CC=C1 \|&1:0,4,5,6,11,13,14,16,17,19,24,r\|

Safety Data

Safety Statements	24/25 less more
WGK Germany	3
HS Code	29389090
Storage Class	11 - Combustible Solids
Hazard Classifications	Acute Tox. 4 Oral

Hazard Information

Description

Picroliv is a hepatoprotective mixture of compounds that is isolated from an herb native to the Himalayas. Picroside I is an iridoid glycoside found in picroliv. By itself, picroside I blocks changes in acid phosphatase activity, phospholipid levels, and lipid peroxide production induced by D-galactosamine in rat liver. Picroside I also enhances neurite outgrowth in PC12D cells induced by basic fibroblast growth factor and 7S nerve growth factor when given at 60 μM. At concentrations as low as 5 μM, picroside I enhances the ATPase activity of the efflux transporter P-glycoprotein.

Chemical Properties

Yellow needle-shaped crystals, soluble in methanol, derived from Picrorhizoma Coptidis.

Uses

Picroside I acts as an oxygen free radical scavenger and thus promotes anti-inflammatory activity and may be used in the treatment of arthritis.

in vivo

Picroside I (20 mg/kg, o.p, 12 d) reduces AHR in the experimental asthma model and reduces OVA-associated IgE levels^[2].

Animal Model:	Ovalbumin (OVA) systematic sensitization BALB/c mice model^[2]
Dosage:	0.2, 2.0 and 20 mg/kg
Administration:	Orally, once daily, from day 20 to day 32
Result:	Inhibited allergen-triggered inflammatory cell infiltration.

IC 50

STAT6

References

[1] C. GIRISH Suresh C P. Drug development for liver diseases: focus on picroliv, ellagic acid and curcumin[J]. Fundamental & Clinical Pharmacology, 2008, 22 6: 623-632. DOI: 10.1111/j.1472-8206.2008.00618.x
[2] YOGESH DWIVEDI. Picroliv and its Components Kutkoside and Picroside I Protect Liver Against Galactosamine-Induced Damage in Rats[J]. Basic & Clinical Pharmacology & Toxicology, 1992, 71 5: 383-387. DOI: 10.1111/j.1600-0773.1992.tb00566.x
[3] PING LI . Potentiation of nerve growth factor-action by picrosides I and II, natural iridoids, in PC12D cells[J]. European journal of pharmacology, 2000, 406 2: Pages 203-208. DOI: 10.1016/s0014-2999(00)00662-2
[4] PING LI. Picrosides I and II, selective enhancers of the mitogen-activated protein kinase-dependent signaling pathway in the action of neuritogenic substances on PC12D cells[J]. Life sciences, 2002, 71 15: Pages 1821-1835. DOI: 10.1016/s0024-3205(02)01949-5
[5] I A NAJAR. Modulation of P-glycoprotein ATPase activity by some phytoconstituents.[J]. Phytotherapy Research, 2010: 454-458. DOI: 10.1002/ptr.2951

Spectrum Detail

Supplier

Shanghai YuanYe Biotechnology Co., Ltd.

Telephone 15026964105

Websitehttps://www.shyuanye.com

Chembest Research Laboratories Limited

Telephone021-20908456

Websitehttp://www.BioChemBest.com

Beijing HwrkChemical Technology Co., Ltd

Telephone89508211 18501085097

Websitehttp://www.hwrkchemical.com

Adamas Reagent, Ltd.

Telephone400-6009262 15618770481

Websitehttp://www.tansoole.com

China DongFan Chemical Co.,LTD

Telephone86-0571-85151182

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList14819/0_EN.htm

Sichuan Kulinan Technology Co., Ltd

Telephone400-1166-196 18981987031

Websitehttp://www.hx-r.com/

China Langchem Inc.

Telephone0086-21-58956006

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList19141/0_EN.htm

Aktin Chemicals, Inc.

Telephone86-28-85159085

Websitehttp://www.aktinchem.com

Shenzhen Sungening Bio-Tech Co., Ltd

Telephone+86-0755-89668383

Websitehttp://www.sungening.com/en

Dalian Meilun Biotech Co., Ltd.

Telephone0411-62910999 13889544652

Websitehttp://www.meilunbio.com/

BioBioPha Co., Ltd.

Telephone0871-65217109

Websitehttp://www.biobiopha.com

Chengdu Ai Keda Chemical Technology Co., Ltd.

Telephone4008-755-333 18080918076

Websitehttp://www.aikeshiji.com

Chengdu Biopurify Phytochemicals Ltd.

Telephone+86-028-82633397 18982077548

Websitehttp://www.biopurify.cn

Chengdu Climax Biotech Co., Ltd.

Telephone028-83311324 1278112614

Websitehttp://www.climax-biotech.com

Shanghai Winherb Medical Technology Co., Ltd.

Telephone17301719108 13341702378

Websitehttp://www.winherb.cn

Beijing HuaMeiHuLiBiological Chemical

Telephone010-56205725

Websitehttp://www.huabeibiochem.com/

Shanghai Ruji Biology Technology Co., Ltd.

Telephone+86-21-65211385-8001 36031160

Websitehttp://www.chinaruji.com/

Shanghai Tauto Biotech Co., Ltd.

Telephone021-51320588

Websitehttp://www.tautobiotech.com/

1of4

Related Products

Send Inquriy