(1,5-Cyclooctadiene)(pyridine)(tricyclohexylphosphine)iridium(I) hexafluorophosphate

Reaction

1. Iridium catalyst used for the highly enantioselective hydrogenation of α,β-unsaturated esters.
2. Iridium catalyst used for the stereoselective catalytic hydrogenation and conjugate reduction of 4methylitaconate derivatives bearing a chiral auxiliary.
3. Iridium catalyst used in the synthesis of thiophene-based TAK-779 analogues via C-H arylation.
4. Iridium catalyst used in the practical synthetic approach to chiral (α-chloroalkyl)boronic esters via an iridiumcatalyzed, chemoselective hydrogenation of chloro-substituted alkenyl boronates.
5. Iridium catalyst used in the regioselective C-H activation and hydrogen-isotope exchange of non-aromatic unsaturated functionality.

Chemical Properties

orange crystals. Air stable for days, but long term storage under N2 and in the dark recommended.

Uses

1,5-Cyclooctadiene(pyridine)(tricyclohexylphosphine)iridium(I) hexafluorophosphate is used as a catalyst for hydrogenation of mono-, di-, tri-, and tetra-substituted substrates and the isomerization and hydroboration of alkenes. It is also used in isotope exchange reactions, especially the direct exchange of a hydrogen atom with its isotopes deuterium and tritium. Carbonyl groups are also known to direct the hydrogenation by the Crabtree catalyst is highly regioselective.

reaction suitability

core: iridium
reagent type: catalyst