Uses
JMS-17-2 hydrochloride is a potent and selective CX3CR1 antagonist with an IC50 of 0.32 nM. JMS-17-2 hydrochloride impairs metastatic seeding and colonization of breast cancer cells[1].
in vivo
JMS-17-2 (10 mg/kg; aministered i.p.; twice a day for three weeks) causes a dramatic reduction of tumors in both skeleton and visceral organs in SCID mice[1].
| Animal Model: | SCID mice (~25g) with MDA-231 xenograft[1] |
| Dosage: | 10 mg/kg |
| Administration: | Aministered i.p.; twice a day for three weeks |
| Result: | Caused a dramatic reduction of tumors in both skeleton and visceral organs. |
References
[1] Shen F, et al. Novel Small-Molecule CX3CR1 Antagonist Impairs Metastatic Seeding and Colonization of Breast Cancer Cells. Mol Cancer Res. 2016 Jun;14(6):518-27. DOI:
10.1158/1541-7786.MCR-16-0013
