2341841-07-2

Name	JMS 17-2 hydrochloride
CAS	2341841-07-2
Molecular Formula	C25H27Cl2N3O
MDL Number	MFCD34470322
Molecular Weight	456.41
MOL File	2341841-07-2.mol

Synonyms

JMS 17-2 hydrochloride

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Chemical Properties

solubility

Soluble to 100 mM in DMSO and to 50 mM in ethanol

Hazard Information

Uses

JMS-17-2 hydrochloride is a potent and selective CX3CR1 antagonist with an IC50 of 0.32 nM. JMS-17-2 hydrochloride impairs metastatic seeding and colonization of breast cancer cells[1].

in vivo

JMS-17-2 (10 mg/kg; aministered i.p.; twice a day for three weeks) causes a dramatic reduction of tumors in both skeleton and visceral organs in SCID mice^[1].

Animal Model:	SCID mice (~25g) with MDA-231 xenograft^[1]
Dosage:	10 mg/kg
Administration:	Aministered i.p.; twice a day for three weeks
Result:	Caused a dramatic reduction of tumors in both skeleton and visceral organs.

storage

Desiccate at RT

References

[1] Shen F, et al. Novel Small-Molecule CX3CR1 Antagonist Impairs Metastatic Seeding and Colonization of Breast Cancer Cells. Mol Cancer Res. 2016 Jun;14(6):518-27. DOI:10.1158/1541-7786.MCR-16-0013

Supplier

Shanghai Hongye Biotechnology Co. Ltd

Telephone400-9205774 400-920-5774

Websitehttp://www.glpbio.cn/

Shanghai Merlot Chemical Co., LTD

Telephone 15821661757

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList1059485/0_EN.htm

RD International Technology Co., Limited

Telephone 18024082417

Websitehttps://www.ruidiresearch.com

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

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