Description
Complex diseases, like cancer, may best be countered by compounds that affect multiple targets. AD57 is a polypharmacological cancer therapeutic, in that it is designed to modulate multiple targets related to cancer.
1 In
Drosophila, it potently inhibits the receptor tyrosine kinase RET (IC
50 = 2 nM) and reduces the activity of numerous other kinases by more than 80% when given at 1 μM.
1 Most notably, AD57 interferes with kinases downstream of RET, including Src, Raf, and S6K, providing further efficacy in preventing signaling leading to invasion, proliferation, and metabolism relevant to cancer.
1
References
1. Dar, A.C., Das, T.K., Shokat, K.M., et al.
Chemical genetic discovery of targets and anti-targets for cancer polypharmacology Nature 486,80-84(2012).
