2320261-72-9

Complex diseases, like cancer, may best be countered by compounds that affect multiple targets. AD57 is a polypharmacological cancer therapeutic, in that it is designed to modulate multiple targets related to cancer.¹ In Drosophila, it potently inhibits the receptor tyrosine kinase RET (IC₅₀ = 2 nM) and reduces the activity of numerous other kinases by more than 80% when given at 1 μM.¹ Most notably, AD57 interferes with kinases downstream of RET, including Src, Raf, and S6K, providing further efficacy in preventing signaling leading to invasion, proliferation, and metabolism relevant to cancer.¹

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1. Dar, A.C., Das, T.K., Shokat, K.M., et al. Chemical genetic discovery of targets and anti-targets for cancer polypharmacology Nature 486,80-84(2012).