Description
HC Toxin is a cell-
permeable, reversible inhibitor of histone deacetylases (HDACs) (IC
50 = 30 nM). Through its effects on HDACs, HC toxin has been shown to up-
regulate the expression of 15-
lipoxygenase-
1 in colorectal cancer cells and induce fetal hemoglobin in human primary erythroid cells. HC Toxin is a cyclic tetrapeptide first isolated from
H. carbonum (now
C. carbonum), a pathogen of maize.
Uses
HC Toxin is an HDAC inhibitor. Cyclic tetrapeptide[1] fungal toxin selectively toxic to plants with susceptible host genotype (2)
Definition
ChEBI: A homodetic cyclic tetrapeptide made up from L-alanyl, D-alanyl, L-prolyl and 2-amino-8-oxo-9,10-epoxydecanoyl residues.
Biochem/physiol Actions
Cyclic tetrapeptide fungal toxin selectively toxic to plants with susceptible host genotype.
References
[1] G BROSCH. Inhibition of maize histone deacetylases by HC toxin, the host-selective toxin of Cochliobolus carbonum.[J]. Plant Cell, 1995, 7 11: 1941-1950. DOI:
10.1105/tpc.7.11.1941[2] S J DARKIN-RATTRAY. Apicidin: a novel antiprotozoal agent that inhibits parasite histone deacetylase.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1996, 93 23: 13143-13147. DOI:
10.1073/pnas.93.23.13143[3] H. KAMITANI. Expression of 15-lipoxygenase-1 is regulated by histone acetylation in human colorectal carcinoma.[J]. Carcinogenesis, 2001, 22 1 1: 187-191. DOI:
10.1093/carcin/22.1.187[4] HUA CAO George S. Histone deacetylase inhibitor FK228 is a potent inducer of human fetal hemoglobin[J]. American Journal of Hematology, 2006, 81 12: 981-983. DOI:
10.1002/ajh.20676[5] WALTON J. HC-toxin.[J]. Phytochemistry, 2020, 67 14 1: 1406-1413. DOI:
10.32388/5s7act
